Osteosarcoma of the jaws in Koreans: analysis of 26 cases
نویسندگان
چکیده
Objectives In order to assess clinical behavior, response to treatment, and factors influencing prognosis of Korean patients with osteosarcoma of the jaws (OSJ). Materials and Methods A retrospective study of clinical, and pathological records of 26 patients with OSJ treated at the Department of Oral and Maxillofacial Surgery in Yonsei University Dental Hospital from 1990 to March 2017. Results Of 26 patients, there were 9 men (34.6%) and 17 women (65.4%). Twenty-one of 26 patients had osteosarcoma of the mandible, and 5 of 26 patients had osteosarcoma of the maxilla. The histopathology of OSJ is highly variable, ranging from chondroblastic type (6 out of 26), osteoblastic type (10 out of 26), fibroblastic type (2 out of 26), to the rare variants like mixed type, small cell osteosarcoma types and more. All patients underwent gross total excision and only a few patients underwent neoadjuvant chemotherapy. Postoperative chemotherapy was given to most of the patients as adjuvant treatment or in combination with radiotherapy. The overall survival rate was 73.1% with an overall 2-year survival rate of 83.3%. The overall 5-,10-,15-year survival rates in this study were 73.5%, 73.5%, 49%, respectively. Using Kaplan-Meier analysis with log rank tests, the size of tumor (T-stage), and resection margins were found to affect the survival rate significantly. The chemotherapy was not significantly associated with improved survival rate. Conclusion Surgical resection with a clear margin is the most important factor in disease survival. The role of chemotherapy and radiotherapy in OSJ remains controversial, and deserves further studies.
منابع مشابه
MANDIBULAR OSTEOSARCOMA MISTAKEN FOR PERICORONAL INFECTION A CASE REPORT
Osteosarcoma is relatively rare in the jaws and variable in presentation, thus its recognition may be quite confusing and delay diagnosis and treatment. Also, in contrast to most malignancies, osteosarcoma is usually encountered earlier in life and may clinically resemble features of more common oral entities such as chronic osteomyelitis, fibrous dysplasia, osteoblastic metastatic carcinom...
متن کاملOstegogenic Sarcoma with Epithelial Differentiation (Carcinosarcoma): Report of Two Cases
Epitheloid osteosarcoma (carcinosarcoma) of the bone is a rare malignant tumor and only a few cases have been reported in the literature. In this study, we report two cases of osseous carcinosarcoma (epitheloid osteosarcoma) with immunohistochemical studies. The morphological and immunohistochemical data in these two cases support the theory of divergent differentiation of primitive, uncommitt...
متن کاملگزارش یک مورد نادر استئوبلاستومای فک بالا در کودک هفت ساله: گزارش موردی
Background: Osteoblastoma is one of the rarest primary benign bone tumors which accounts for 1% of all bone neoplasms and 3.5% of benign bone tumors, with the potential for local invasion and recurrence. Osteoblastoma is not homogeneous. Differences in histological details have led to the division of these lesions into subtypes. The histologic features in most cases are distinctive, there are v...
متن کاملMaxillofacial Malignancy in Pregnancy; Report of Two Cases
Pregnancy is a physiological period in a woman’s life. It is well known that some pathological changes have been reported to be more common in pregnancy than other stages of the life. It seems that primary tumors have a tendency to progress more rapidly in pregnancy due to hormonal alterations or increased expression of some growth factors. The exact relationship between pregnancy and malignanc...
متن کاملprognostic importance of the pathologic fracture and surgical options in osteosarcoma: a retrospective clinical study
Background & Aims: Osteosarcoma is one of the most prevalent malignant bone tumors . This study is designed to assess the prognostic effect of pathologic fracture and treatment options on survival of patients with osteosarcoma. Materials & Methods: In this study, prognosis of 106 patients with limb osteosarcoma, which were treated at three hospitals in Tehran from April to August 2012 ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 43 شماره
صفحات -
تاریخ انتشار 2017